Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia

Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia

Sepsis, a pathology resulting from excessive inflammatory response that leads to multiple organ failure, is a major cause of mortality in intensive care units. Macrophages play an important role in the pathophysiology of sepsis. Accumulating evidence has suggested an upregulated rate of aerobic glyc...

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Bibliographic Details
Main Authors: Jiean Xu, Lina Wang, Qiuhua Yang, Qian Ma, Yaqi Zhou, Yongfeng Cai, Xiaoxiao Mao, Qingen Da, Tammy Lu, Yunchao Su, Zsolt Bagi, Rudolf Lucas, Zhiping Liu, Mei Hong, Kunfu Ouyang, Yuqing Huo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
inflammation
glycolysis
PFKFB3
macrophage
endotoxemia
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.745810/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.745810/full

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