Improving Soluble Expression of SARS-CoV-2 Spike Priming Protease TMPRSS2 with an Artificial Fusing Protein

Improving Soluble Expression of SARS-CoV-2 Spike Priming Protease TMPRSS2 with an Artificial Fusing Protein

SARS-CoV-2 relies on the recognition of the spike protein by the host cell receptor ACE2 for cellular entry. In this process, transmembrane serine protease 2 (TMPRSS2) plays a pivotal role, as it acts as the principal priming agent catalyzing spike protein cleavage to initiate the fusion of the cell...

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Bibliographic Details
Main Authors: Xiao Ye, Xue Ling, Min Wu, Guijie Bai, Meng Yuan, Lang Rao
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
TMPRSS2
SARS-CoV-2
artificial protein
protein expression
protease
Online Access:https://www.mdpi.com/1422-0067/24/13/10475

Internet

https://www.mdpi.com/1422-0067/24/13/10475

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