Backstabbing P-gp: Side-Chain Cleaved Ecdysteroid 2,3-Dioxolanes Hyper-Sensitize MDR Cancer Cells to Doxorubicin without Efflux Inhibition

Backstabbing P-gp: Side-Chain Cleaved Ecdysteroid 2,3-Dioxolanes Hyper-Sensitize MDR Cancer Cells to Doxorubicin without Efflux Inhibition

P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is a major problem in cancer chemotherapy that urgently requires novel approaches. Our previous studies showed certain ecdysteroid derivatives as promising chemo-sensitizers against MDR and non-MDR cancer c...

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Bibliographic Details
Main Authors: Attila Hunyadi, József Csábi, Ana Martins, Joseph Molnár, Attila Balázs, Gábor Tóth
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
ecdysteroid metabolite
poststerone acetonide
ABCB1 efflux transporter
cancer
multi-drug resistance
chemo-sensitization
combination therapy
Online Access:http://www.mdpi.com/1420-3049/22/2/199

Internet

http://www.mdpi.com/1420-3049/22/2/199

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