Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node

The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammaso...

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Bibliographic Details
Main Authors: Nikolaos Chatziandreou, Yagmur Farsakoglu, Miguel Palomino-Segura, Rocco D’Antuono, Diego Ulisse Pizzagalli, Federica Sallusto, Veronika Lukacs-Kornek, Mariagrazia Uguccioni, Davide Corti, Shannon J. Turley, Antonio Lanzavecchia, Michael C. Carroll, Santiago F. Gonzalez
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
IL-1α
alarmin
lymph node macrophages
inflammatory cascade
cytokine storm
IFN-β
influenza
vaccine
CD11b+ DC
MCP-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302073

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http://www.sciencedirect.com/science/article/pii/S2211124717302073

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