Accumulation of endogenous adenosine improves cardiomyocyte metabolism via epigenetic reprogramming in an ischemia-reperfusion model

Accumulation of endogenous adenosine improves cardiomyocyte metabolism via epigenetic reprogramming in an ischemia-reperfusion model

Adenosine kinase (ADK) plays the major role in cardiac adenosine metabolism, so that inhibition of ADK increases myocardial adenosine levels. While the cardioprotective actions of extracellular adenosine against ischemia/reperfusion (I/R) are well-established, the role of cellular adenosine in prote...

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Bibliographic Details
Main Authors: Peng Wang, Rifeng Gao, Tingting Wu, Jinyan Zhang, Xiaolei Sun, Fan Fan, Cong Wang, Sanli Qian, Bingyu Li, Yunzeng Zou, Yuqing Huo, John Fassett, Yingjie Chen, Junbo Ge, Aijun Sun
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
Adenosine
Ischemia-reperfusion
ADK
IGF-1
Epigenetics
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002859

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http://www.sciencedirect.com/science/article/pii/S2213231723002859

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