Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.

Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.

Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids. This pathway is present in bacteria, fungi, and plants but absent in...

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Bibliographic Details
Main Authors: Wen-Chi Cheng, Yen-Fu Chen, Hung-Jung Wang, Kai-Cheng Hsu, Shuang-Chih Lin, Tzu-Jung Chen, Jinn-Moon Yang, Wen-Ching Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3306394?pdf=render

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http://europepmc.org/articles/PMC3306394?pdf=render

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