Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains.

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains.

SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on these biochemical properties, enabling rapid assessmen...

Full description

Bibliographic Details
Main Authors: Tyler N Starr, Allison J Greaney, Cameron M Stewart, Alexandra C Walls, William W Hannon, David Veesler, Jesse D Bloom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010951

Internet

https://doi.org/10.1371/journal.ppat.1010951

Similar Items