Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells

Abstract The protein kinases DYRK1A and DYRK1B are pivotal regulators of cell cycle progression by promoting cell cycle exit into quiescence. DYRK1B appears to play a more important role in cancer cell quiescence than DYRK1A, as evidenced by its overexpression or copy number variations in human tumo...

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Bibliographic Details
Main Authors: Vincent Andreas Vorwerk, Gerrit Wilms, Aaron Babendreyer, Walter Becker
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-74190-1