Effects of melatonin on DNA damage induced by cyclophosphamide in rats

Effects of melatonin on DNA damage induced by cyclophosphamide in rats

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The antioxidant and free radical scavenger properties of melatonin have been well described in the literature. In this study, our objective was to determine the protective effect of the pineal gland hormone against the DNA damage induced by cyclophosphamide (CP), an anti-tumor agent t...

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Bibliographic Details
Main Authors: S.G. Ferreira, R.A. Peliciari-Garcia, S.A. Takahashi-Hyodo, A.C. Rodrigues, F.G. Amaral, C.M. Berra, S. Bordin, R. Curi, J. Cipolla-Neto
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Melatonin
Cyclophosphamide
Chromosomal aberration
DNA fragmentation
Comet assay
Xpf expression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300278&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300278&lng=en&tlng=en

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