Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)

Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)

<i>FAH domain containing protein 1</i> (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle. Guided by a high-resolution X-ray structure of FAHD1 liganded by oxalate, the enzymatic mechanism of substrate processing is...

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Bibliographic Details
Main Authors: Alexander K. H. Weiss, Richard Wurzer, Patrycia Klapec, Manuel Philip Eder, Johannes R. Loeffler, Susanne von Grafenstein, Stefania Monteleone, Klaus R. Liedl, Pidder Jansen-Dürr, Hubert Gstach
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
FAHD1
enzyme inhibitor
mitochondria
ODx
oxaloacetate
Online Access:https://www.mdpi.com/1420-3049/26/16/5009

Internet

https://www.mdpi.com/1420-3049/26/16/5009

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