Gamma-aminobutyric acid type A receptor alpha 4 coordinates autophagy, inflammation, and immunometabolism to promote innate immune activation

Gamma-aminobutyric acid type A receptor alpha 4 coordinates autophagy, inflammation, and immunometabolism to promote innate immune activation

Gamma-aminobutyric acid type A receptor (GABAAR), the ionotropic receptor of GABA, is expressed in macrophages and in the nervous system; however, its role in innate immunity is unknown. Herein, we identified myeloid GABAAR subunit α4 (Gabra4) as a critical regulator of autophagy and a promoter of h...

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Bibliographic Details
Main Authors: Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Sang Min Jeon, In Soo Kim, June-Young Lee, Jun Young Heo, Sang-Hee Lee, Jin-Woo Bae, Jin-Man Kim, Jin Bong Park, Eun-Kyeong Jo
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autophagy Reports
Subjects:
gabra4
mycobacteria
infection
inflammation
ampk
macrophages
mitochondrial oxidative phosphorylation
immunometabolism
sepsis
Online Access:http://dx.doi.org/10.1080/27694127.2023.2181915

Internet

http://dx.doi.org/10.1080/27694127.2023.2181915

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