Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

Abstract Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impa...

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Bibliographic Details
Main Authors: Masayo Fujita, Yoko Hagino, Yukio Takamatsu, Yuka Shimizu, Yoshiki Takamatsu, Kazutaka Ikeda, Makoto Hashimoto
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Neuropsychopharmacology Reports
Subjects:
β‐synuclein
behavior analysis
Lewy body diseases
nonmotor symptoms
transgenic mice
Online Access:https://doi.org/10.1002/npr2.12009

Internet

https://doi.org/10.1002/npr2.12009

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