Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

Summary: The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and HSC function is unclear. Here, we report that mic...

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Bibliographic Details
Main Authors: Karolina Komorowska, Alexander Doyle, Martin Wahlestedt, Agatheeswaran Subramaniam, Shubhranshu Debnath, Jun Chen, Shamit Soneji, Ben Van Handel, Hanna K.A. Mikkola, Kenichi Miharada, David Bryder, Jonas Larsson, Mattias Magnusson
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317515

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http://www.sciencedirect.com/science/article/pii/S2211124717317515

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