Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.

Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino acid diversity is confined to seven variable (V) regions, and generation of sequence diversity within the V regions occurs via...

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Bibliographic Details
Main Authors: Michelle J Lin, Austin M Haynes, Amin Addetia, Nicole A P Lieberman, Quynh Phung, Hong Xie, Tien V Nguyen, Barbara J Molini, Sheila A Lukehart, Lorenzo Giacani, Alexander L Greninger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-09-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0009753

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https://doi.org/10.1371/journal.pntd.0009753

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