Order Under Uncertainty: Robust Differential Expression Analysis Using Probabilistic Models for Pseudotime Inference.

Single cell gene expression profiling can be used to quantify transcriptional dynamics in temporal processes, such as cell differentiation, using computational methods to label each cell with a 'pseudotime' where true time series experimentation is too difficult to perform. However, owing...

Full description

Bibliographic Details
Main Authors: Kieran R Campbell, Christopher Yau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-11-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5117567?pdf=render