Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na<sup>+</sup> and Erg-Mediated K<sup>+</sup> Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line

Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na<sup>+</sup> and Erg-Mediated K<sup>+</sup> Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line

Carbamazepine (CBZ, Tegretol<sup>®</sup>) is an anticonvulsant used in the treatment of epilepsy and neuropathic pain; however, several unwanted effects of this drug have been noticed. Therefore, the regulatory actions of CBZ on ionic currents in electrically excitable cells need to be r...

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Bibliographic Details
Main Authors: Po-Ming Wu, Hsin-Yen Cho, Chi-Wu Chiang, Tzu-Hsien Chuang, Sheng-Nan Wu, Yi-Fang Tu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
carbamazepine (Tegretol<sup>®</sup>, 5H-dibenzo[b,f]azepine-5-carboxamide)
voltage-gated Na<sup>+</sup> current
window Na<sup>+</sup> current
persistent Na<sup>+</sup> current
voltage-dependent hysteresis
<i>erg</i>-mediated K<sup>+</sup> current
Online Access:https://www.mdpi.com/1422-0067/23/14/7892

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https://www.mdpi.com/1422-0067/23/14/7892

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