Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Linkage-specific ubiquitination often leads to distinct cellular events. It has been difficult to establish definitively the requirement for a particular linkage in mammalian degradation pathways due to the inability to deplete endogenous ubiquitin while maintaining cell viability. The E3 ubiquitin...

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Bibliographic Details
Main Authors: Li Zhang, Ming Xu, Elena Scotti, Zhijian J. Chen, Peter Tontonoz
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein receptor
lysosomal protein degradation
proteasomal protein degradation
E3 ubiquitin ligase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520421777

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http://www.sciencedirect.com/science/article/pii/S0022227520421777

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