The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis

The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis

Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis. However, upon inflammation, the sharp increase in protein production requires additional mechanisms t...

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Bibliographic Details
Main Authors: Timothy French, Nicole Israel, Henning Peter Düsedau, Anne Tersteegen, Johannes Steffen, Clemens Cammann, Eylin Topfstedt, Daniela Dieterich, Thomas Schüler, Ulrike Seifert, Ildiko Rita Dunay
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma
immunoproteasome
neuroinflammation
cerebral toxoplasmosis
LMP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.619465/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.619465/full

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