DrSim: Similarity Learning for Transcriptional Phenotypic Drug Discovery

DrSim: Similarity Learning for Transcriptional Phenotypic Drug Discovery

Transcriptional phenotypic drug discovery has achieved great success, and various compound perturbation-based data resources, such as connectivity map (CMap) and library of integrated network-based cellular signatures (LINCS), have been presented. Computational strategies fully mining these resource...

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Bibliographic Details
Main Authors: Zhiting Wei, Sheng Zhu, Xiaohan Chen, Chenyu Zhu, Bin Duan, Qi Liu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Metric learning
Transcriptional profile similarity
Drug annotation
Drug repositioning
LINCS
Online Access:http://www.sciencedirect.com/science/article/pii/S167202292200122X

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http://www.sciencedirect.com/science/article/pii/S167202292200122X

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