Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis
Periodontitis is a common type of inflammatory bone loss, and cell-free DNA (cfDNA) can be a major source that enhances the periodontal tissue destruction. Here, the authors show that a cfDNA-scavenging approach is able to ameliorate periodontitis by using nanoparticulate cfDNA scavenger.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33492-6 |
| _version_ | 1828161303241293824 |
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| author | Hanyao Huang Weiyi Pan Yifan Wang Hye Sung Kim Dan Shao Baoding Huang Tzu-Chieh Ho Yeh-Hsing Lao Chai Hoon Quek Jiayu Shi Qianming Chen Bing Shi Shengmin Zhang Lei Zhao Kam W. Leong |
| author_facet | Hanyao Huang Weiyi Pan Yifan Wang Hye Sung Kim Dan Shao Baoding Huang Tzu-Chieh Ho Yeh-Hsing Lao Chai Hoon Quek Jiayu Shi Qianming Chen Bing Shi Shengmin Zhang Lei Zhao Kam W. Leong |
| author_sort | Hanyao Huang |
| collection | DOAJ |
| description | Periodontitis is a common type of inflammatory bone loss, and cell-free DNA (cfDNA) can be a major source that enhances the periodontal tissue destruction. Here, the authors show that a cfDNA-scavenging approach is able to ameliorate periodontitis by using nanoparticulate cfDNA scavenger. |
| first_indexed | 2024-04-12T00:36:29Z |
| format | Article |
| id | doaj.art-93703e2f9a7c40a7b3a4f9319e5fd435 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T00:36:29Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-93703e2f9a7c40a7b3a4f9319e5fd4352022-12-22T03:55:09ZengNature PortfolioNature Communications2041-17232022-10-0113111810.1038/s41467-022-33492-6Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitisHanyao Huang0Weiyi Pan1Yifan Wang2Hye Sung Kim3Dan Shao4Baoding Huang5Tzu-Chieh Ho6Yeh-Hsing Lao7Chai Hoon Quek8Jiayu Shi9Qianming Chen10Bing Shi11Shengmin Zhang12Lei Zhao13Kam W. Leong14State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAdvanced Biomaterials and Tissue Engineering Center and Department of Biomedical Engineering, Huazhong University of Science and TechnologyDepartment of Biomedical Engineering, Columbia UniversityDepartment of Biomedical Engineering, Columbia UniversityDepartment of Biomedical Engineering, Columbia UniversityDepartment of Biomedical Engineering, Columbia UniversityDepartment of Biomedical Engineering, Columbia UniversityDepartment of Biomedical Engineering, Columbia UniversityDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of MichiganState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAdvanced Biomaterials and Tissue Engineering Center and Department of Biomedical Engineering, Huazhong University of Science and TechnologyState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Biomedical Engineering, Columbia UniversityPeriodontitis is a common type of inflammatory bone loss, and cell-free DNA (cfDNA) can be a major source that enhances the periodontal tissue destruction. Here, the authors show that a cfDNA-scavenging approach is able to ameliorate periodontitis by using nanoparticulate cfDNA scavenger.https://doi.org/10.1038/s41467-022-33492-6 |
| spellingShingle | Hanyao Huang Weiyi Pan Yifan Wang Hye Sung Kim Dan Shao Baoding Huang Tzu-Chieh Ho Yeh-Hsing Lao Chai Hoon Quek Jiayu Shi Qianming Chen Bing Shi Shengmin Zhang Lei Zhao Kam W. Leong Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis Nature Communications |
| title | Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis |
| title_full | Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis |
| title_fullStr | Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis |
| title_full_unstemmed | Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis |
| title_short | Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis |
| title_sort | nanoparticulate cell free dna scavenger for treating inflammatory bone loss in periodontitis |
| url | https://doi.org/10.1038/s41467-022-33492-6 |
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