Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold

Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold

β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated its scaffold. Systematic SAR studies led to the discovery of compounds 27f and 39f, which exhibited potent inh...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Yuan Gao, Jilong Duan, Xiawen Dang, Yinghui Yuan, Yu Wang, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Taylor & Francis Group 2023-12-01
Sraith:Journal of Enzyme Inhibition and Medicinal Chemistry
Ábhair:
β-Elemene
Histone deacetylase inhibitor
Hybrid drugs
Lymphoma
Rochtain ar líne:https://www.tandfonline.com/doi/10.1080/14756366.2023.2195991

Ar líne

https://www.tandfonline.com/doi/10.1080/14756366.2023.2195991

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