A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice

A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice

Heparin-induced thrombocytopenia (HIT) is a complication caused by administration of the anticoagulant heparin. Although the number of patients with HIT has drastically increased because of coronavirus disease 2019 (COVID-19), the currently used thrombin inhibitors for HIT therapy do not have antido...

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Bibliographic Details
Main Authors: Masanobu Nagano, Kazuki Kubota, Asuka Sakata, Rei Nakamura, Toru Yoshitomi, Koji Wakui, Keitaro Yoshimoto
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
aptamer
thrombin
avidity
antidote
heparin-induced thrombocytopenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002111

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http://www.sciencedirect.com/science/article/pii/S2162253123002111

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