FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

Abstract FUS is an RNA-binding protein involved in familiar forms of ALS and FTLD that also assembles into fibrillar cytoplasmic aggregates in some neurodegenerative diseases without genetic causes. The self-adhesive prion-like domain in FUS generates reversible condensates via the liquid–liquid pha...

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Bibliographic Details
Main Authors: Emilie Bertrand, Clément Demongin, Ioana Dobra, Juan Carlos Rengifo-Gonzalez, Anastasia S. Singatulina, Maria V. Sukhanova, Olga I. Lavrik, David Pastré, Loic Hamon
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34558-1

Internet

https://doi.org/10.1038/s41598-023-34558-1

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