Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway

Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway

The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in myocardial I/R injury. We hypothesized that propofol prevents myoca...

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Bibliographic Details
Main Authors: Shengqiang Li, Zhen Lei, Xiaomei Yang, Meng Zhao, Yonghao Hou, Di Wang, Shuhai Tang, Jingxin Li, Jingui Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
Akt
ferroptosis
heart
ischemia/reperfusion injury
propofol
p53
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.841410/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.841410/full

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