MLN2238 exerts its anti-tumor effects via regulating ROS/JNK/mitochondrial signaling pathways in intrahepatic cholangiocarcinoma

MLN2238 exerts its anti-tumor effects via regulating ROS/JNK/mitochondrial signaling pathways in intrahepatic cholangiocarcinoma

Background: Intrahepatic Cholangiocarcinoma (iCCA) is a highly malignant tumor with limited treatment options that contributes largely to cancer-related deaths worldwide. Compared with traditional transcriptomic analysis, single-cell RNA sequencing (scRNA-seq) is emerging as a more advanced and popu...

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Bibliographic Details
Main Authors: Hao Xu, Guangyu Xu, Qianhui Xu, Chang Xu, Xiaohu Zhou, Yang Bai, Lu Yin, Yuan Ding, Weilin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
intrahepatic cholangiocarcinoma
proteasome inhibitors
autophagy
apoptosis
ROS/JNK/mitochondrial signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1040847/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1040847/full

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