Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation

Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation

Epidermal growth factor family receptor (EGFR) is commonly overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR)-T therapy, but as EGFR is also expressed at lower levels in healthy tissues a therapeutic strategy must balance antigenic responsiveness against...

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Bibliographic Details
Main Authors: Scott McComb, Tina Nguyen, Alex Shepherd, Kevin A. Henry, Darin Bloemberg, Anne Marcil, Susanne Maclean, Ahmed Zafer, Rénald Gilbert, Christine Gadoury, Robert A. Pon, Traian Sulea, Qin Zhu, Risini D. Weeratna
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
cellular immunotherapy
EGFR
CAR optimization
CAR-T
hinge domain
cancer selectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.864868/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.864868/full

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