Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric <i>Fok</i>I Nuclease Domains

Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric <i>Fok</i>I Nuclease Domains

Persistent hepatitis B virus (HBV) infection remains a serious medical problem worldwide, with an estimated global burden of 257 million carriers. Prophylactic and therapeutic interventions, in the form of a vaccine, immunomodulators, and nucleotide and nucleoside analogs, are available. Vaccination...

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Bibliographic Details
Main Authors: Tiffany Smith, Prashika Singh, Kay Ole Chmielewski, Kristie Bloom, Toni Cathomen, Patrick Arbuthnot, Abdullah Ely
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
HBV
cccDNA
obligate heterodimeric TALENs
Sharkey
Online Access:https://www.mdpi.com/1999-4915/13/7/1344

Internet

https://www.mdpi.com/1999-4915/13/7/1344

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