Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Somatic mutations in genes coding for splicing factors, e.g., SF3B1, U2AF1, SRSF2, and others are found in approximately 50% of patients with myelodysplastic syndromes (MDS). These mutations have been predicted to frequently occur early in the mutational hierarchy of the disease, therefore, making...

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Bibliografski detalji
Glavni autori: Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak
Format: Članak
Jezik:English
Izdano: Ferrata Storti Foundation 2020-09-01
Serija:Haematologica
Online pristup:https://haematologica.org/article/view/10017

Internet

https://haematologica.org/article/view/10017

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