Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...

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Bibliographic Details
Main Authors: Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
cholesterol
G-protein coupled receptor
hedgehog signaling
Online Access:https://elifesciences.org/articles/20304

Internet

https://elifesciences.org/articles/20304

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