Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development

Abstract Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity. Rare MYSM1 mutations in human patients result in an inherited bone marrow failure syndrome, highlighting the biomedical significance of MYSM1 in the hematopoietic system. We...

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Bibliographic Details
Main Authors: Yue Liang, Garvit Bhatt, Lin Tze Tung, HanChen Wang, Joo Eun Kim, Marwah Mousa, Viktoria Plackoska, Katalin Illes, Anna A. Georges, Philippe Gros, Linda Henneman, Ivo J. Huijbers, Bhushan Nagar, Anastasia Nijnik
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27486-7

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https://doi.org/10.1038/s41598-023-27486-7

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