Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis

Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis

Abstract Oral microbiome dysbiosis mediates chronic periodontal disease, gut microbial dysbiosis, and mucosal barrier disfunction that leads to steatohepatitis via the enterohepatic circulation. Improving this dysbiosis towards health may improve liver disease. Treatment with antibiotics and probiot...

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Bibliographic Details
Main Authors: Ryutaro Kuraji, Changchang Ye, Chuanjiang Zhao, Li Gao, April Martinez, Yukihiro Miyashita, Allan Radaic, Pachiyappan Kamarajan, Charles Le, Ling Zhan, Helene Range, Masataka Sunohara, Yukihiro Numabe, Yvonne L. Kapila
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-024-00476-x

Internet

https://doi.org/10.1038/s41522-024-00476-x

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