Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial

Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial

BackgroundPsilocybin may help treat obsessive–compulsive disorder (OCD). To date, only one open-label study of psilocybin for OCD exists, necessitating further investigation with a randomized controlled design. The neural correlates of psilocybin’s effects on OCD have also not been studied.Objective...

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Bibliographic Details
Main Authors: Terence H. W. Ching, Rachael Grazioplene, Calvin Bohner, Stephen A. Kichuk, Giuliana DePalmer, Elizabeth D’Amico, Jeffrey Eilbott, Anastasia Jankovsky, Michelle Burke, Jamila Hokanson, Brad Martins, Chelsea Witherow, Prerana Patel, Lucia Amoroso, Henry Schaer, Christopher Pittenger, Benjamin Kelmendi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Psychiatry
Subjects:
psilocybin
psychedelic
psychological support
obsessive–compulsive disorder
mental health
neuroimaging
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1178529/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1178529/full

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