Optimization and Appraisal of Nintedanib-Loaded Mixed Polymeric Micelles as a Potential Nanovector for Non-Invasive Pulmonary Fibrosis Mitigation

Optimization and Appraisal of Nintedanib-Loaded Mixed Polymeric Micelles as a Potential Nanovector for Non-Invasive Pulmonary Fibrosis Mitigation

Background/Objectives: Nintedanib (NTD), a triple tyrosine kinase receptor inhibitor, is the recommended first-line tackling option for idiopathic pulmonary fibrosis (IPF). Nevertheless, the adequacy of NTD is curtailed by issues associated with its low solubility, first-pass effect, poor bioavailab...

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Bibliographic Details
Main Authors: Heba M. Aboud, Shahira F. El Menshawe, Nada H. Mohammed, Alaa S. Tulbah, Adel A. Ali
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Pharmaceuticals
Subjects:
pulmonary fibrosis
non-invasive targeting
nintedanib
polymeric mixed micelles
statistical optimization
pharmacokinetics
Online Access:https://www.mdpi.com/1424-8247/17/10/1275

Internet

https://www.mdpi.com/1424-8247/17/10/1275

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