High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform

A 3D cell culture chip was used for high-throughput screening of a human neural progenitor cell line. The differential toxicity of 24 compounds was determined on undifferentiated and differentiating NPCs. Five compounds led to significant differences in IC50 values between undifferentiated and diffe...

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Bibliographic Details
Main Authors: Gregory J. Nierode, Brian C. Perea, Sean K. McFarland, Jorge F. Pascoal, Douglas S. Clark, David V. Schaffer, Jonathan S. Dordick
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Stem Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111630220X