Conversion of Hyperpolarized [1-<sup>13</sup>C]Pyruvate in Breast Cancer Cells Depends on Their Malignancy, Metabolic Program and Nutrient Microenvironment

Conversion of Hyperpolarized [1-<sup>13</sup>C]Pyruvate in Breast Cancer Cells Depends on Their Malignancy, Metabolic Program and Nutrient Microenvironment

Hyperpolarized magnetic resonance spectroscopy (MRS) is a technology for characterizing tumors in vivo based on their metabolic activities. The conversion rates (<i>k<sub>pl</sub></i>) of hyperpolarized [1-<sup>13</sup>C]pyruvate to [1-<sup>13</sup>C]l...

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Bibliographic Details
Main Authors: Martin Grashei, Philipp Biechl, Franz Schilling, Angela M. Otto
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
breast cancer cells
<sup>13</sup>C-glucose metabolomics
hyperpolarized <sup>13</sup>C-pyruvate
glycolysis
LDH
nutrient deprivation
Online Access:https://www.mdpi.com/2072-6694/14/7/1845

Internet

https://www.mdpi.com/2072-6694/14/7/1845

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