GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

The mechanisms promoting hepatoblastoma (HB) progression through Wnt/β-catenin signaling are unclear. Here, the authors show that the Wnt/ β-catenin axis induces GREB1 expression and nuclear localization, and suppresses TGFβ pathway, and propose GREB1 as a therapeutic target in HB.

Bibliographic Details
Main Authors: Shinji Matsumoto, Taku Yamamichi, Koei Shinzawa, Yuuya Kasahara, Satoshi Nojima, Takahiro Kodama, Satoshi Obika, Tetsuo Takehara, Eiichi Morii, Hiroomi Okuyama, Akira Kikuchi
Format: Article
Language:English
Published: Nature Portfolio 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11533-x

Internet

https://doi.org/10.1038/s41467-019-11533-x

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