AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2‐STAT3 signaling pathway

AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2‐STAT3 signaling pathway

Abstract Background The aryl hydrocarbon receptor (AhR) is a critical regulator of the pathogenesis of autoimmune disorders. We aimed to investigate the therapeutic effect of the AhR agonist tapinarof during the development of systemic lupus erythematosus (SLE). Methods MRL/lpr mice were intraperito...

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Bibliographic Details
Main Authors: Ying Zhang, Yanyan Pan, Peiyi Zhang, Fang Wang, Ying Han, Kailin Li, Wen Jiang, Jue Wang, Yun Luan, Qian Xin
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Immunity, Inflammation and Disease
Subjects:
AhR
SLE
T follicular helper cell
Online Access:https://doi.org/10.1002/iid3.903

Internet

https://doi.org/10.1002/iid3.903

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