In Vitro Evaluation of Drug–Drug Interaction Potential of Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor

In Vitro Evaluation of Drug–Drug Interaction Potential of Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor

Epetraborole (EBO) is a boron-containing inhibitor of bacterial leucyl-tRNA synthetase, with potent activity against nontuberculous mycobacteria (NTM) and Gram-negative bacteria, including <i>Burkholderia pseudomallei</i>. EBO is being developed for the treatment of NTM lung disease and...

Full description

Bibliographic Details
Main Authors: Afshin Shafiee, Sanjay Chanda
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
epetraborole
drug–drug interaction
bacterial leucyl-tRNA synthetase
<i>Mycobacterium avium</i> complex
melioidosis
in vitro studies
Online Access:https://www.mdpi.com/1424-8247/17/1/120

Similar Items

Similar Items