Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

Background: A strong association of obesity and insulin resistance with increased circulating levels of branched-chain and aromatic amino acids and decreased glycine levels has been recognized in human subjects for decades. Scope of review: More recently, human metabolomics and genetic studies have...

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Bibliographic Details
Main Authors: Phillip J. White, Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, Christopher B. Newgard
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Molecular Metabolism
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782100106X