The HLA class I immunopeptidomes of AAV capsid proteins

The HLA class I immunopeptidomes of AAV capsid proteins

IntroductionCellular immune responses against AAV vector capsid represent an obstacle for successful gene therapy. Previous studies have used overlapping peptides spanning the entire capsid sequence to identify T cell epitopes recognized by AAV-specific CD8+ T cells. However, the repertoire of pepti...

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Bibliographic Details
Main Authors: Carlos A. Brito-Sierra, Megan B. Lannan, Laurent P. Malherbe, Robert W. Siegel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
aav
HLA class I
gene therapy
CD8+
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212136/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212136/full

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