Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

Abstract Fast‐twitch muscles are less susceptible to disuse atrophy, activate the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, and increase protein synthesis under prolonged muscle disuse conditions. However, the mechanism underlying prolonged muscle disuse‐induced mTORC1 si...

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Bibliographic Details
Main Authors: Munehiro Uda, Toshinori Yoshihara, Noriko Ichinoseki‐Sekine, Takeshi Baba
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Physiological Reports
Subjects:
mitochondria
mTORC1
prenylation
skeletal muscle atrophy
small GTPase
Online Access:https://doi.org/10.14814/phy2.15969

Internet

https://doi.org/10.14814/phy2.15969

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