Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions

Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions

The application of model-informed drug discovery and development (MID3) approaches in the early stages of drug discovery can help determine feasibility of drugging a target, prioritize between targets, or define optimal drug properties for a target product profile (TPP). However, applying MID3 in ea...

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Bibliographic Details
Main Authors: Diana H. Marcantonio, Andrew Matteson, Marc Presler, John M. Burke, David R. Hagen, Fei Hua, Joshua F. Apgar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
QSP
MID3
dose prediction
mAb
biotherapeutic
mechanistic PKPD
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.864768/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.864768/full

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