Rapamycin inhibits cardiac hypertrophy by promoting autophagy via the MEK/ERK/Beclin-1 pathway

Rapamycin inhibits cardiac hypertrophy by promoting autophagy via the MEK/ERK/Beclin-1 pathway

Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved. Here, the effect of rapamycin was examined using...

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Bibliographic Details
Main Authors: Changqian eWang, Gu eJun, Wei eHu, Zhi-ping eSong, Yue-guang eChen, Da-dong eZhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Physiology
Subjects:
Autophagy
cardiac hypertrophy
rapamycin
Aortic banding
MEK/ERK signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00104/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00104/full

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