Uterine mesenchymal tumors harboring ALK fusions and response to ALK-targeted therapy

Uterine mesenchymal tumors harboring ALK fusions and response to ALK-targeted therapy

Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare but aggressive malignancy that is often misdiagnosed. Approximately 50% of uterine IMTs (UMT) harbor rearrangements involving the ALK gene on chromosome 2p23 with subsequent overexpression of the ALK protein. Molecular characterization...

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Bibliographic Details
Main Authors: Chrisann Kyi, Claire F. Friedman, Jennifer J. Mueller, Ryma Benayed, Marc Ladanyi, Maria Arcila, Soo Ryum Yang, Martee L. Hensley, Sarah Chiang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Gynecologic Oncology Reports
Subjects:
Sarcoma
Uterine neoplasms
ALK
Tyrosine Kinase inhibitor (TKI)
Inflammatory Myofibroblastic Tumor
Leiomyosarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578921001569

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http://www.sciencedirect.com/science/article/pii/S2352578921001569

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