The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival

The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival

Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of available targeted therapy. Expression of protein lin‐28 homolog B (LIN28B), a regulator of developmental timing, is u...

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Bibliographic Details
Main Authors: Shubin W. Shahab, Christianna M. Roggeveen, Jiarong Sun, Haritha Kunhiraman, Leon F. McSwain, Kyle Juraschka, Sachin A. Kumar, Olivier Saulnier, Michael D. Taylor, Matthew Schniederjan, Robert W. Schnepp, Tobey J MacDonald, Anna Marie Kenney
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Molecular Oncology
Subjects:
1632
let‐7
HI‐TOPK‐032
Group 3 medulloblastoma
LIN28B
PBK
Online Access:https://doi.org/10.1002/1878-0261.13477

Internet

https://doi.org/10.1002/1878-0261.13477

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