Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase
Abstract Histone lysine methyltransferase SUV420H1, which is responsible for site-specific di-/tri-methylation of histone H4 lysine 20 (H4K20), has crucial roles in DNA-templated processes, including DNA replication, DNA damage repair, and chromatin compaction. Its mutations frequently occur in huma...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-12-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-023-00620-5 |