Micellar Hyaluronidase and Spiperone as a Potential Treatment for Pulmonary Fibrosis

Micellar Hyaluronidase and Spiperone as a Potential Treatment for Pulmonary Fibrosis

Concentration of hyaluronic acid (HA) in the lungs increases in idiopathic pulmonary fibrosis (IPF). HA is involved in the organization of fibrin, fibronectin, and collagen. HA has been proposed to be a biomarker of fibrosis and a potential target for antifibrotic therapy. Hyaluronidase (HD) breaks...

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Bibliographic Details
Main Authors: Evgenii Skurikhin, Pavel Madonov, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Lubov Sandrikina, Andrey Artamonov, Alexander Dygai
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
idiopathic pulmonary fibrosis
hyaluronic acid
electron beam synthesis
poloxamer-hyaluronidase
spiperone
transforming growth factor beta
Online Access:https://www.mdpi.com/1422-0067/22/11/5599

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https://www.mdpi.com/1422-0067/22/11/5599

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