Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients

Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients

The NOD-, LRR-, and pyrin-domain-containing protein 3 (NLRP3) inflammasome is a node of intracellular stress pathways and a druggable target which integrates mitochondrial stress and inflammatory cascades. While a body of evidence suggests the involvement of the NLRP3 inflammasome in numerous diseas...

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Bibliographic Details
Main Authors: Xinyang Zhou, Shehan M. Fernando, Alexander Y. Pan, Rebecca Laposa, Kathryn R. Cullen, Bonnie Klimes-Dougan, Ana C. Andreazza
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
NLRP3
ASC specks
IL-1 beta
bipolar
depression
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/22/12513

Internet

https://www.mdpi.com/1422-0067/22/22/12513

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