Current Trends in Sirtuin Activator and Inhibitor Development

Current Trends in Sirtuin Activator and Inhibitor Development

Sirtuins are NAD<sup>+</sup>-dependent protein deacylases and key metabolic regulators, coupling the cellular energy state with selective lysine deacylation to regulate many downstream cellular processes. Humans encode seven sirtuin isoforms (Sirt1-7) with diverse subcellular localizatio...

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Bibliographic Details
Main Authors: Karina L. Bursch, Christopher J. Goetz, Brian C. Smith
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
sirtuins
epigenetics
lysine deacylation
drug development
Online Access:https://www.mdpi.com/1420-3049/29/5/1185

Internet

https://www.mdpi.com/1420-3049/29/5/1185

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