The Possible Mechanism of Amyloid Transformation Based on the Geometrical Parameters of Early-Stage Intermediate in Silico Model for Protein Folding

The Possible Mechanism of Amyloid Transformation Based on the Geometrical Parameters of Early-Stage Intermediate in Silico Model for Protein Folding

The specificity of the available experimentally determined structures of amyloid forms is expressed primarily by the two- and not three-dimensional forms of a single polypeptide chain. Such a flat structure is possible due to the β structure, which occurs predominantly. The stabilization of the fibr...

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Bibliographic Details
Main Authors: Irena Roterman, Katarzyna Stapor, Dawid Dułak, Leszek Konieczny
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid
secondary structure
α-helix unfolding
β-structure
left-handed α-helix
hydrogen bonds
Online Access:https://www.mdpi.com/1422-0067/23/16/9502

Internet

https://www.mdpi.com/1422-0067/23/16/9502

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